Khat (Catha edulis) generates reactive oxygen species and promotes hepatic cell apoptosis via MAPK activation
نویسندگان
چکیده
منابع مشابه
Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts.
Khat chewing is widely practiced in Eastern Africa and the Middle East. Khat is genotoxic to cells within the oral mucosa, and several studies have suggested an association between khat use and oral lesions like hyperkeratosis and oral cancer. This study investigated the mechanism of khat-induced cytotoxicity using primary normal human oral keratinocytes (NOK) and fibroblasts (NOF). Khat induce...
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BACKGROUND Khat (Catha edulis) is a controversial plant having a euphoretic effect, at the same time part of culture in many countries such as Africa and Arabian Peninsula. The presence of amphetamine-like substance, cathinone and cathine make this plant banned in many countries. Many neurological and other system related studies have been carried out in this plant, but the lack of toxicity stu...
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Khat (Catha edulis Forsk) is a flowering evergreen plant in Eastern Africa and Southwestern Arabia. Consumption of Khat has been associated with the development of oral cancer, but its mechanism of action on the molecular level remains unclear. The present study demonstrated the cytotoxic effect of khat extracts on the human breast cancer cell line MDA-MB-231. Trypan blue exclusion assays, flow...
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متن کاملCatha Edulis (khat), a Sex Depressant, Euphoriant in History
This article traces the history of the Khat which is an intoxicant and also a sexual depressant. The author establishes that its origion is Abyssinia and it is brought to Arabia where it is commonly used even by Muslims. If Khat is consumed in excess it may impair the health but moderate quantity is beneficial.
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2013
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2013.1394